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CD45 Mouse anti-Human, Pacific Orange™, Clone: HI30, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD4530TR

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Catalog No. 50-112-1424


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Description

Description

PerCP conjugates are excited by the 488 nm line of the argon-ion laser and have a large Stokes shift, providing minimal spectral overlap into the R-PE (phycoerythrin) channel.

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
Specifications

Specifications

CD45
Monoclonal
Pacific Orange™
PTPRC
Liquid
PTPRC
CD45 antigen
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
HI30
PBS with 4mg/mL BSA and 0.1% sodium azide
P08575
B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase; receptor type; c polypeptide; receptor-type tyrosine-protein phosphatase C; HCD45
Mouse
IgG1
25 tests
4° C, store in dark
Primary
5788
Documents
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