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CD45RO Mouse anti-Human, PerCP, Clone: UCHL1, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD45RO31

Catalog No. 50-112-1432


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Description

Description

PerCP conjugates are excited by the 488 nm line of the argon-ion laser and have a large Stokes shift, providing minimal spectral overlap into the R-PE (phycoerythrin) channel.

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Specifications

Specifications

CD45RO
Monoclonal
PerCP
PTPRC
Liquid
PTPRC
Human CD45RO
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
UCHL1
PBS with 4mg/mL BSA, sucrose and 0.1% sodium azide
P08575
B220, CD45, CD45R, GP180, LCA, LY5, T200
Mouse
IgG2a
0.5 mL
4° C, store in dark
Primary
5788
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