CD46 Mouse anti-Human, Alexa Fluor 532, Clone: 122.2, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233159AF532
DescriptionCD46 Monoclonal antibody specifically detects CD46 in Human samples. It is validated for Western Blot,Flow Cytometry,ELISA,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen).
|Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen|
|AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen|
|Store at 4°C in the dark.|
|CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.|
|ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot|
|Alexa Fluor™ 532|
|50 mM sodium borate with 0.05% sodium azide|
|A recombinant protein fragment specific for human CD46 was used as the immunogen.|
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