CD46 Mouse anti-Human, Clone: 169-1-EA.3, Abnova™
Mouse monoclonal antibody raised against human CD46.
Manufacturer: Abnova Corporation MAB12895
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq]
|Mouse monoclonal antibody raised against human CD46.|
|In 50mM Na|
|Store at 4°C. Do not freeze. Open under aseptic conditions.|
|Flow Cytometry, Immunohistochemistry (PFA fixed), Western Blot|
|Flow Cytometry Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) Western Blot The optimal working dilution should be determined by the end user.|
|Human PBL and EBV transformed LCL.|
|Protein A purification|
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