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CD49b (Integrin alpha 2) Armenian Hamster anti-Mouse, Clone: HMa2, eBioscience™

Armenian Hamster Monoclonal Antibody

Manufacturer:  Invitrogen 14049182

Encompass

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Catalog No. 50-126-24


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Description

Description

Description: The HMalpha2 monoclonal antibody reacts with mouse CD49b, the 150 kDa integrin alpha2 subunit. The complex of CD49b non-covalently associated with integrin beta1 (CD29), also known as VLA-2, is a receptor for collagen and laminin. This complex is expressed by some CD4^+ T cells, IEL, NK cells, platelets and epithelial cells. Applications Reported: The HM alpha2 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistochemical staining of frozen tissue (IHC-F). It has also been reported for use in in vitro functional assays (Please use Functional Grade purified HMa2, cat. 16-0491, in functional assays.). Applications Tested: The HM alpha2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

GTP-binding proteins (G-proteins) play a critical role in signal transduction by coupling receptors to effectors. The intracellular consequences of G-protein activation include second messenger generation, protein phosphorylation, ion channel activation, gene induction, cell growth, and differentiation. Gi belongs to the pertussis toxin sensitive G-proteins. Gi consists of three different subtypes of a-subunits (ai1, ai2 and ai3).
Specifications

Specifications

CD49b (Integrin alpha 2)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q62469
Itga2
Affinity chromatography
RUO
16398
4° C
Liquid
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation
HMa2
Unconjugated
Itga2
BR, CD49B, GPIa, VLA-2, VLAA2, ITGA2
Armenian Hamster
100 μg
Primary
Mouse
Antibody
IgG
SDS
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