CD49d (Integrin alpha 4) Rabbit anti-Human, Invitrogen
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Invitrogen MA527947
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. The alpha 4 chain associates with either the beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4 beta1 and alpha4 beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4 beta7. It was also demonstrated that the HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4 beta7, the gut mucosal homing receptor for peripheral T cells.
|CD49d (Integrin alpha 4)|
|Immunohistochemistry, Western Blot|
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide|
|A peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4)|
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