CD5 Mouse anti-Human, Rat, Porcine, Bovine, Canine, Chicken, Several Species, Alexa Fluor™ 594, Clone: CD5/54/F6, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP234593AF594
DescriptionCD5 Monoclonal specifically detects CD5 in Human, Rat, Porcine, Bovine, Chicken, Equine, Guinea Pig, Monkey, Rabbit samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.
|Alexa Fluor 594|
|50 mM sodium borate with 0.05% sodium azide|
|A synthetic peptide from the intracellular region of human CD5|
|Human, Rat, Porcine, Bovine, Canine, Chicken, Equine, Guinea Pig, Monkey, Rabbit|
|Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)|
|Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen|
|CD5 antigen, CD5 antigen (p56-62), CD5 molecule, LEU1T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, T1|
|Protein A or G purified|
|Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (∼10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.|
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