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CD63 Mouse anti-Human, FITC, Clone: CLB-gran/12 (CLB-180), Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD63014

Catalog No. 50-112-1452


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Description

Description

Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.
Specifications

Specifications

CD63
Monoclonal
FITC
CD63
Liquid
CD63
Human CD63
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
CLB-gran/12 (CLB-180)
PBS with 4mg/mL BSA and 0.1% sodium azide
P08962
LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Mouse
IgG1
2 mL
4° C, store in dark
Primary
967
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