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CD69 Hamster anti-Murine, Brilliant Ultraviolet 737, Clone: H1.2F3, BD Horizon™

Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 612793

Catalog No. BDB612793


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Description

Description

The H1.2F3 monoclonal antibody specifically binds to CD69 (Very Early Activation antigen), an 85 kDa disulfide-linked homodimer of differentially glycosylated subunits. CD69 is a C-type lectin, most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. Its expression is rapidly induced upon activation of lymphocytes (T, B, NK, and NK-T cells), neutrophils, and macrophages. CD69 is expressed also on thymocytes that are undergoing positive selection; its role in that process is unclear. H1.2F3 mAb augments PMA-induced T-cell stimulation and IFN- γ-induced macrophage stimulation. IL-2-activated NK cells express CD69, and H1.2F3 mAb induces redirected lysis of FcR-bearing target cells by NK cells.

The antibody was conjugated to BD Horizon BUV737 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye is a tandem fluorochrome of BD Horizon BUV395 with an Ex Max of 348-nm and an acceptor dye with an Em Max at 737-nm. BD Horizon Brilliant BUV737 can be excited by the ultraviolet laser (355 nm) and detected with a 740/35 filter. Due to the excitation of the acceptor dye by other laser lines, there may be significant spillover into channels detecting Alexa Fluor™ 700-like dyes (e.g., 712/20-nm filter).

Specifications

Specifications

CD69
H1.2F3
Brilliant Ultraviolet 737
Affinity Purified
Mouse Dendritic Epidermal T Cell Line Y245
Affinity Chromatography
RUO
Primary
Mouse
Flow Cytometry
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Hamster
IgG1, λ3
50 μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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