CD7 Monoclonal Antibody (MG34), FITC, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA112024

Catalog No. 01-670-747

Description

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.

Specifications

• Antigen: CD7
• Classification: Monoclonal
• Concentration: 0.02 mg/mL
• Formulation: PBS with 0.2% carrier protein and 0.08% sodium azide
• Gene Accession No.: P09564
• Gene Symbols: CD7
• Immunogen: T-acute lymphoblastic leukemia (T-ALL) cells
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry
• Clone: MG34
• Conjugate: FITC
• Gene: CD7
• Gene Alias: Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 924
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid

Safety and Handling

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