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CD70 Rat anti-Mouse, Clone: FR70, eBioscience™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen 14070181

Encompass

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Catalog No. 50-126-92

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Description: The FR70 monoclonal antibody reacts with mouse CD70, a 30-33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation. Applications Reported: The FR70 antibody has been reported for use in flow cytometric analysis, and immunoprecipitation. FR70 has also been reported in blocking of CD70 in vitro . (Please use Functional Grade purified FR70, cat. 16-0701, in functional assays.). Applications Tested: The FR70 antibody has been tested by flow cytometric analysis of LPS-stimulated mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Specifications

Specifications

CD70
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O55237
Cd70
Affinity chromatography
RUO
21948
4° C
Liquid
Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization
FR70
Unconjugated
Cd70
CD27LG, Cd27l, Tnfsf7
Rat
50 μg
Primary
Mouse
Antibody
IgG2b κ
SDS
Documents
Product Certifications
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