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CD8 alpha Monoclonal Antibody (AD4(15)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA170077

Catalog No. PIMA170077


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Description

Description

MA1-70077 detects CD8a in mouse samples. MA1-70077 has been successfully used in flow cytometry procedures. The MA1-70077 immunogen is C57BL/6.

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
Specifications

Specifications

CD8 alpha
Monoclonal
1 mg/mL
Cd8a
CD8, Leu-2, MAL, p32, CD8a
Mouse
Protein G
RUO
12525
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Flow Cytometry
AD4(15)
Unconjugated
P01731
CD8A
C57BL/6.
250 μg
Primary
Mouse
Antibody
IgM
SDS
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Documents

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