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CD8 Mouse anti-Human, Qdot® 705, Clone: 3B5, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen Q10059

Catalog No. 50-113-8146


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Description

Description

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
Specifications

Specifications

CD8
Monoclonal
Qdot® 705
CD8B
Liquid
CD8A, CD8B
Recognizes the CD8 antigen
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
3B5
0.05M borate with 1M betaine and 0.05% sodium azide; pH 8.3
P01732, P10966
CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta
Mouse
IgG2a
100 μL
4° C, store in dark
Primary
925, 926
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