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CD80 (B7-1) Armenian Hamster anti-Canine, Mouse, Porcine, Biotin, Clone: 16-10A1, eBioscience™ Non-distribution product as customer accommodation.

Armenian Hamster Monoclonal Antibody

$87.50 - $273.00

Specifications

Antigen CD80 (B7-1)
Clone 16-10A1
Target Species Canine, Mouse, Porcine
Conjugate Biotin
Isotype IgG
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-116-34 Non-distribution product as customer accommodation.
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Invitrogen
13080181
50 μg Each for $87.50
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50-116-35 Non-distribution product as customer accommodation.
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Invitrogen
13080182
100 μg Each for $164.00
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50-116-36 Non-distribution product as customer accommodation.
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Invitrogen
13080185
500 μg Each for $273.00
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Description

Description

Description: The 16-10A1 monoclonal antibody reacts with mouse CD80 (B7-1), a 55 kDa member of the Ig superfamily. CD80 is expressed by macrophages, dendritic cells and activated B cells. In addition, activated T cells express this antigen. CD80 has high affinity for binding to two T cell surface antigens, CD28 and CD152 (CTLA-4). The interaction of CD28 and CD152 with CD80 is crucial in T-B cell communication leading to activation of T and B cells, respectively. Applications Reported: The 16-10A1 antibody has been reported for use in flow cytometric analysis. Applications Tested: The 16-10A1 antibody has been tested by flow cytometric analysis of activated mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Specifications

Specifications

CD80 (B7-1)
Canine, Mouse, Porcine
IgG
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
16-10A1
Biotin
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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