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CD80 Monoclonal Antibody (OTI7H3), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Supplier: OriGene TA501669
Description
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.Specifications
CD80 | |
Monoclonal | |
0.64 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
P33681 | |
CD80 | |
Full length human recombit protein of human CD80 produced in HEK293T cell. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI7H3 | |
Unconjugated | |
CD80 | |
B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 | |
Mouse | |
Affinity Chromatography | |
RUO | |
941 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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