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CD88 (C5aR1) Monoclonal Antibody (20/70), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  Invitrogen 46088282

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Catalog No. 46-088-282


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Description

Description

Description: This 20/70 monoclonal antibody recognizes mouse CD88 also known as C5aR1. CD88 is a complement receptor widely expressed on cells of the myeloid lineage. Clone 20/70 has been reported to block the binding of C5a to murine CD88. Applications Reported: This 20/70 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 20/70 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. PerCP-eFluor 710 emits at 710 nm and is excited with the blue laser (488 nm); it can be used in place of PerCP-Cyanine5.5. We recommend using a 710/50 bandpass filter, however, the 695/40 bandpass filter is an acceptable alternative. Please make sure that your instrument is capable of detecting this fluorochrome. Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (Product No. 00-8222-49) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product No.

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
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Specifications

Specifications

CD88 (C5aR1)
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide, pH 7.2
P30993
C5AR1
RBL-2H3 transfected cells expressing murine C5aR
100 μg
Primary
Mouse
Antibody
IgG2b κ
Flow Cytometry
20/70
PerCP-eFluor 710
C5AR1
anaphylatoxin C5a receptor, C5A, C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5a ligand, C5a Receptor, C5AR, C5a-R, C5AR1, C5r1, Cd88, CD88 antigen, complement C5a receptor, complement C5a receptor 1, complement component 5 receptor 1, complement component 5, receptor 1, complement component 5a receptor 1, D7Msu1
Rat
Affinity chromatography
RUO
12273
4° C, store in dark, DO NOT FREEZE!
Liquid
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