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CD88 (C5aR1) Rat anti-Mouse, PE, Clone: 20/70, eBioscience Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 12088280

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Catalog No. 12-088-280


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Description

Description

Description: This 20/70 monoclonal antibody recognizes mouse CD88 also known as C5aR1. CD88 is a complement receptor widely expressed on cells of the myeloid lineage. Clone 20/70 has been reported to block the binding of C5a to murine CD88. Applications Reported: This 20/70 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 20/70 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
Specifications

Specifications

CD88 (C5aR1)
Monoclonal
0.2 mg/ml
PBS with 0.09% sodium azide; pH 7.2
P30993
C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor-like; C5a anaphylatoxin receptor; C5a ligand; C5a-R; CD88; complement C5a receptor; complement component 5 receptor 1
Rat
IgG2b, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12273
Flow Cytometry
20/70
PE
C5ar1
Liquid
C5ar1
RBL-2H3 transfected cells expressing murine C5aR
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
SDS
Documents
Product Certifications
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