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CD88 Mouse anti-Human, Brilliant Violet 786, Clone: D53-1473, BD Optibuild™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 742320

Catalog No. BDB742320


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Description

Description

The D53-1473 monoclonal antibody specifically recognizes CD88, a 40 kDa polypeptide expressed on granulocytes, monocytes and macrophages. CD88 is a G type protein-coupled receptor with seven transmembrane domains. It binds to C5a, theαchain of the complement component C5. C5a is cleaved from C5 during complement activation. The binding of C5a to C5a receptor (C5aR, CD88) on granulocytes leads to various effects including shedding of selectins, upregulation of adhesion molecules, chemotaxis, granule exocytosis and activation of NADPH oxidase. Clone D53-1473 was developed using a known C5aR N-terminal extracellular hydrophilic region (a.a. 1-31) peptide as immunogen. This antibody is useful in inflammation and chemotaxis research.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
Specifications

Specifications

CD88
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
C5a Receptor, C5aR, C5a anaphylatoxin receptor
Mouse IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
D53-1473
Brilliant Violet 786
Affinity Purified
Murine
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon BV786 under optimal conditions that minimize unconjugated dye and antibody.
RUO
Primary
Human
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