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CD8 alpha Rat anti-Mouse, PerCP, Clone: 5H10, Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MCD0831

Catalog No. 50-113-8104


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Description

Description

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
Specifications

Specifications

CD8 alpha
Monoclonal
PerCP
Cd8a
Liquid
Cd8a
Con A-stimulated BALB/c splenic T cells
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
5H10
PBS with BSA and 0.1% sodium azide
P01731
CD8, Leu-2, MAL, p32, CD8a
Rat
IgG2b
500 μL
4° C
Primary
12525
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