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CD95 (APO-1/Fas) Mouse anti-Human, FITC, Clone: SM1/23, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen BMS140FI

Catalog No. 50-177-96


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Description

Description

Description: BMS140 is suitable as primary antibody for staining in FACS analysis. BMS140FI can be used for direct staining of cells. BMS140BT can be used in a two-step procedure using the biotin-(strept-)avidin system. Functional studies: BMS140 was found to block induction of apoptosis induced by clone SM1/1 or other commercial anti APO-1 antibodies. Optimal dilutions should be determined by the individual laboratory for each application. Applications Tested: Flow Cytometry. Purity: >95%. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
Specifications

Specifications

CD95 (APO-1/Fas)
Monoclonal
10 μL/Test
TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
P25445
ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
SM1/23
FITC
FAS
Liquid
FAS
IgG2b
100 Tests
4° C
Primary
355
SDS
Documents
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