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FAS Mouse anti-Human, Pacific Blue™, Clone: DX2, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$144.00 - $378.00

Specifications

Antigen FAS
Clone DX2
Target Species Human
Conjugate Pacific Blue™
Isotype IgG1
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-113-8131 Non-distribution product as customer accommodation. View Documents Invitrogen
MHCD9528
500 μL Each for $378.00
Add to cart
 
50-113-8132 Non-distribution product as customer accommodation. View Documents Invitrogen
MHCD9528TR
25 tests Each for $144.00
Add to cart
 
Description

Description

Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

Fas ligand (FasL, CD 95L) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor Fas (CD 95, Apo-1) is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. As a member of the TNF-cytokine family FasL induces apoptosis when interacting with its receptor Fas. FasL may exist as either membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of FasL to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. FasL is predomitly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye. FasL expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney. The Fas/FasL system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer. It is assumed that induction of apoptosis through FasL is predomitly involved in anti-viral immune responses.
Specifications

Specifications

FAS
Human
IgG1
Monoclonal
Liquid
Antibody
4° C
DX2
Pacific Blue™
Flow Cytometry
Primary
Monoclonal
PBS with BSA and 0.1% sodium azide
RUO
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