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Cdc20 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550925

Catalog No. PA550925


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Description

Description

CDC20 Polyclonal Antibody detects endogenous levels of CDC20 protein.

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Specifications

Specifications

CDC20
Polyclonal
Unconjugated
CDC20
Liquid
CDC20
Synthesized peptide derived from the Internal region of human Cdc20.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q12834, Q9JJ66, Q62623
CDC20, Cell division cycle protein 20 homolog, p55CDC
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
107995, 64515, 991
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