Cdc20 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550925
CDC20 Polyclonal Antibody detects endogenous levels of CDC20 protein.Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
|Synthesized peptide derived from the Internal region of human Cdc20.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|ELISA, Immunohistochemistry, Western Blot|
|PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4|
|Q12834, Q9JJ66, Q62623|
|CDC20, Cell division cycle protein 20 homolog, p55CDC|
|-20° C, Avoid Freeze/Thaw Cycles|
|107995, 64515, 991|
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