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CDCA8 Mouse anti-Human, Clone: OTI4G3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526912

Catalog No. PIMA526912


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Description

Description

CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
Specifications

Specifications

CDCA8
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q53HL2
BOR, BOREALIN, DasraB, MESRGP, Dasra B, borealin, cell division cycle-associated protein 8, dasra-B, hDasra-B, pluripotent embryonic stem cell-related gene 3 protein
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55143
Immunohistochemistry (Paraffin), Western Blot
OTI4G3
Unconjugated
CDCA8
Liquid
CDCA8
Full length human recombit protein of CDCA8 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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