Invitrogen™ CDK7 Monoclonal Antibody (MO-1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA112300

Catalog No. 01-670-993

Description

CDK7 Monoclonal Antibody for Western Blot, ICC/IF, IHC, IP

The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.

Specifications

• Antigen: CDK7
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: P50613
• Gene Symbols: CDK7
• Immunogen: Recombinant 221 amino acid fragment of the C terminus of p40mo15 recognizing a 40kD protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: MO-1
• Conjugate: Unconjugated
• Gene: CDK7
• Gene Alias: 39 KDa protein kinase; 39 protein kinase; AI323415; AI528512; C230069N13; CAK; CAK1; CDK; CDK7; CDK-activating kinase; CDK-activating kinase 1; Cdkn7; cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); cyclin dependent kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; HCAK; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; Mpk-7; OTTHUMP00000222032; OTTHUMP00000222033; p39 Mo15; p39MO15; Protein-tyrosine kinase MPK-7; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; STK1; TFIIH basal transcription factor complex kinase subunit
• Host Species: Mouse
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 1022
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov