CDK8 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA585290
Keep as concentrated solution. Positive Control: A549, H1299, HCT116. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.A family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. The p54/Cdk 8 interacts exclusively with Cyclin C. The Cdk 8 Cyclin C complex activates the kinase. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
|K35 antibody; MGC126074 antibody; MGC126075 antibody; CDK8 antibody; CDK8 protein kinase antibody; mediator of RNA polymerase II transcription subunit CDK8 antibody; mediator complex subunit CDK8 antibody; cyclin-dependent kinase 8 antibody; protein kinase K35 antibody; cell division protein kinase 8 antibody|
|Antigen Affinity Chromatography|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CDK8.|
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