CDK8 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Supplier: Active Motif 61482
DescriptionA family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. The p54/Cdk 8 interacts exclusively with Cyclin C. The Cdk 8 Cyclin C complex activates the kinase. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
|Cdk8; CDK8 protein kinase; Cell division protein kinase 8; cyclin dependent kinase 8; Cyclin-dependent kinase 8; K35; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35; RGD1560888; wu:fk95h11|
|Antigen affinity chromatography|
|-20°C, Avoid Freeze/Thaw Cycles|
|ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot|
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|This antibody was raised against a peptide within the C-terminal region of human CDk8.|
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