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CDKL2 Mouse anti-Human, Clone: OTI5D9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526749

Catalog No. PIMA526749


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Description

Description

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predomitly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
Specifications

Specifications

CDKL2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q92772
Cyclin-dependent kinase-like 2, Serine/threonine-protein kinase KKIAMRE, Protein kinase p56 KKIAMRE, CDKL2,
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8999
Immunohistochemistry (Paraffin), Western Blot
OTI5D9
Unconjugated
CDKL2
Liquid
CDKL2
Human recombit protein fragment corresponding to amino acids 291-493 of CDKL2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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