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CDKN2A p14ARF Rabbit anti-Human, Unconjugated, Polyclonal, Active Motif™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

$135.30 - $534.00

Specifications

Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Antigen CDKN2A p14ARF
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3621 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61690
10 μL
Each for $135.30
Add to cart
 
50-199-3620 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61689
100 μL
Each for $534.00
Add to cart
 
Description

Description

The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These two proteins interact with the upstream proteins: retinoblastoma protein and p53 tumor suppressors, respectively. Each of these proteins has a role in the senescence of primary cells, activates pathways for cell cycle control and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest in a manner that depends on functional p53. The mouse and human ARF proteins have different functions in tumor suppression; this distinction may contribute to the different levels of tumor proneness of these species.
Specifications

Specifications

Polyclonal
Primary
CDKN2A p14ARF
Unconjugated
SDS
Product Certifications
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