CDKN2B Monoclonal Antibody (DCS114.1), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA112294

Catalog No. 01-670-987

Description

The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant. 5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase.

Specifications

• Antigen: CDKN2B
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: P42772
• Gene Symbols: CDKN2B
• Immunogen: His-tagged recombinant full length p15 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: DCS114.1
• Conjugate: Unconjugated
• Gene: CDKN2B
• Gene Alias: AV083695; CDK inhibitory protein; CDK4B inhibitor; CDK4I; Cdkn2b; cyclin dependent kinase inhibitor 2B; Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinases 4 and 6 binding protein; Ink4; INK4B; MTS2; MTS-2; Multiple tumor suppressor 2; p14_CDK inhibitor; p14_INK4B; p14-INK4b; P15; p15 CDK inhibitor; p15(INK4b); p15_INK4B; p15INK4b; p15-INK4b; TP15
• Host Species: Mouse
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 1030
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov