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CDKN2B Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549749

Catalog No. PA549749


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Description

Description

The antibody detects endogenous levels of total CDKN2B protein.

The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant. 5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase. The availability of a monoclonal antibody reacting specifically with p18INK4c enables the subcellular detection and localization of p18INK4c and the measurement of relative differences in p18INK4c levels as a function of cell cycle phase.
Specifications

Specifications

CDKN2B
Polyclonal
Unconjugated
CDKN2B
Liquid
CDKN2B
Synthesized peptide derived from human p15 INK antibody.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P42772, P55271, P55272
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor B
Rabbit
IgG
100 μL
-20°C
Primary
1030, 12579, 25164
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