CDKN2B Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA571734

Catalog No. PIPA571734

Description

The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant. 5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase. The availability of a monoclonal antibody reacting specifically with p18INK4c enables the subcellular detection and localization of p18INK4c and the measurement of relative differences in p18INK4c levels as a function of cell cycle phase.

Specifications

• Antigen: CDKN2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDKN2B
• Gene Alias: Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B; CDKN2B; MTS2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1030
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P42772
• Gene Symbols: CDKN2B
• Immunogen: KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG