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CDT1 Hamster anti-Human, Clone: ID8, Active Motif™ Non-distribution product as customer accommodation.

Hamster Monoclonal Antibody

$116.85 - $356.95

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen CDT1
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3087 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61040
10 μg
Each for $116.85
Add to cart
 
50-199-3086 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61039
100 μg
Each for $356.95
Add to cart
 
Description

Description

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
Specifications

Specifications

Monoclonal
Primary
CDT1
Unconjugated
SDS
Product Certifications
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