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Cefotaxime Sodium Salt, MP Biomedicals™

Catalog Number mp215494791
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Quantity:
1 g
64485-93-4
C16H16N5NaO7S2
477.44
MFCD00079073
AZZMGZXNTDTSME-JUZDKLSSSA-M
Cefotaxime sodium, (6R-(6-a,7-b(Z)))-3-((Acetyloxy) methyl)-7- (((2-amino-4-thiazolyl) (methoxyimio) acetyl) amino)-8- oxo-5-thia-1- azabicyclo (4,2,0) oct-2-ene-2-carboxylic acid, sodium salt
88631411
sodium;(6S,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1
64485-93-4
C16H16N5NaO7S2
477.44
MFCD00079073
AZZMGZXNTDTSME-JUZDKLSSSA-M
Cefotaxime sodium, (6R-(6-a,7-b(Z)))-3-((Acetyloxy) methyl)-7- (((2-amino-4-thiazolyl) (methoxyimio) acetyl) amino)-8- oxo-5-thia-1- azabicyclo (4,2,0) oct-2-ene-2-carboxylic acid, sodium salt
88631411
sodium;(6S,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1

Description

Inhibits bacterial cell wall synthesis. Cefotaxime Sodium Salt, MP Biomedicals is a cephalosporin antibiotic that is active against both gram-negative and gram-positive bacteria. It is used for infections of the respiratory tract, skin, bones, joints, uro

Cefotaxime binds to penicillin-binding proteins (PBPs), which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes. Cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes. Cefotaxime is used to treat a variety of bacterial infections:

  • Good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas
  • Effective against most Gram-positive cocci, except for Enterococcus
  • Active against penicillin-resistant strains of Streptococcus pneumoniae
  • Modest activity against the anaerobic Bacteroides fragilis
  • In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime
Physical Form Powder
Solubility Information Soluble in water (0.05gm/1mL, clear, light yellow solution).
Formula Weight 477.45
Percent Purity ≥95%
Quantity 1 g

Safety and Handling

Recommended Storage Store at 4°C, protect from light.
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