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CENP-B Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Supplier: Active Motif 61288
Description
CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.Specifications
CENP-B | |
Polyclonal | |
Unconjugated | |
CENPB | |
Cenpb; Cenp-b; CENP-B protein; centromere autoantigen B; Centromere protein B; centromere protein B, 80kDa; Major centromere autoantigen B | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
1059 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunoprecipitation, Western Blot | |
Lot-Specific | |
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5 | |
P07199 | |
CENPB | |
This CENP-B antibody was raised against a recombinant protein corresponding to the C-terminal region of human CENP-B. | |
10 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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