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CEP135 Rabbit anti-Canine, Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 244281AP

Catalog No. 50-173-4354


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Description

Description

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Specifications

Specifications

CEP135
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q66GS9
centrosomal protein 135kDa, Centrosomal protein 4, Centrosomal protein of 135 kDa, CEP135, CEP4, KIAA0635
Rabbit
IgG
150 μL
-20°C
Primary
482157, 9662
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
CEP135
Liquid
CEP135
CEP135 Fusion Protein Ag19122
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Canine, Human
Documents
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