CFI Mouse anti-Human, Clone: OX-21, Abnova™
Mouse monoclonal antibody raised against native human CFI.
Manufacturer: Abnova Corporation MAB12907
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq]
|Mouse monoclonal antibody raised against native human CFI.|
|In PBS (0.02% sodium azide).|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ELISA, Flow Cytometry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot|
|ELISA Flow Cytometry Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) Immunoprecipitation Western Blot The optimal working dilution should be determined by the end user.|
|Native purified human CFI.|
|Protein G purification|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok