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CFI Mouse anti-Human, Clone: OX-21, Abnova™

Mouse monoclonal antibody raised against native human CFI.

Manufacturer:  Abnova Corporation MAB12907

Catalog No. 89-933-964


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Description

Description

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq]

Specifications

Specifications

CFI
OX-21
Mouse monoclonal antibody raised against native human CFI.
In PBS (0.02% sodium azide).
C3B-INA/FI/IF/KAF
Mouse
IgG1
125 ug
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
ELISA, Flow Cytometry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
Unconjugated
ELISA Flow Cytometry Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) Immunoprecipitation Western Blot The optimal working dilution should be determined by the end user.
Liquid
CFI
Native purified human CFI.
Protein G purification
RUO
Primary
3426
SDS
Documents
Product Certifications
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