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CHCHD6 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 206391AP

Catalog No. 50-173-3007


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Description

Description

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
Specifications

Specifications

CHCHD6
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BRQ6
CHCHD6, CHCM1, MIC25
Rabbit
IgG
150 μL
-20°C
Primary
84303
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
CHCHD6
Liquid
CHCHD6
CHCHD6 Fusion Protein Ag14700
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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