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Chd5 Rat anti-Human, Mouse, Clone: 5A10, Active Motif™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$135.30 - $534.00

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen Chd5
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3617 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61684
10 μg
Each for $135.30
Add to cart
 
50-199-3616 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61683
100 μg
Each for $534.00
Add to cart
 
Description

Description

CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.
Specifications

Specifications

Monoclonal
Primary
Chd5
Unconjugated
SDS
Product Certifications
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