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CHFR Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550177

Catalog No. PA550177


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Description

Description

The antibody detects endogenous levels of total CHFR protein.

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the  ft.Lys-48 ft.-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of  ft.Lys-63 ft.-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at  ft.Lys-63 ft. are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Specifications

Specifications

CHFR
Polyclonal
Unconjugated
CHFR
Liquid
CHFR
Synthesized peptide derived from Internal of human CHFR.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q96EP1, Q810L3
RNF196
Rabbit
IgG
100 μL
-20°C
Primary
231600, 288734, 55743
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