CHIA Mouse anti-Human, Clone: OTI3H4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527414
DescriptionChitinases are ubiquitous chitin-fragmenting hydrolases. The chitinase Chitotriosidase is capable of cleaving natural chitin and chitin-like substrates in humans and may play a role in immunity against pathogens containing chitin. Activated human macrophages secrete chitotriosidase, and increased plasma levels of chitotriosidase are a feature of patients suffering from Gaucher ft.s disease. Expression of mouse Chitotriosidase is restricted to brain, skin, bone marrow, kidney, tongue, stomach and testis. The homology between chitotriosidase and chitinases found in lower organisms is significant. Acidic mammalian chitinase precursor (AMCase) degrades chitotriose and chitin. AMCase is highly expressed in stomach tissues and is primarily a secreted protein. It is involved in Th2-mediated inflammation and may play a role in asthma and allergic diseases.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|AMCASE, CHIT2, TSA1902, acidic mammalian chitinase, lung-specific protein TSA1902|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of CHIA produced in E.coli|
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