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Chk2 Ab-1 Mouse Monoclonal Antibody, Epredia™
Ensure accurate, reproducible results in western blotting, immunofluorescence and immunoprecipitation experiments with Epredia™ Chk2 Ab-1, Mouse Monoclonal Antibody.
$426.00 - $1422.00
Specifications
| Antigen | Chk2 Ab-1 |
|---|---|
| Clone | 2CHK01; same as DCS-293 |
| Applications | Immunofluorescence, Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Concentration | Quantity | Price | Quantity & Availability | ||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Concentration | Quantity | Price | Quantity & Availability | ||||
|
MS1330P0
|
Epredia
MS1330P0 |
200μg/mL | 100 μL |
Each for $426.00
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MS1330P1
|
Epredia
MS1330P1 |
200μg/mL | 500 μL |
Each for $893.00
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MS1330P
|
Epredia
MS1330P |
200μg/mL | 1 mL |
Each for $1,291.00
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MS1330P1ABX
|
Epredia
MS1330P1ABX |
1mg/mL | 100 μL |
Each for $1,005.00
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MS1330PABX
|
Epredia
MS1330PABX |
1mg/mL | 200 μL |
Each for $1,422.00
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Description
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phophorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.
Host Species: Mouse
Clone: 2CHK01; same as DCS-293
Isotype: IgG1/κ
Species Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Recombinant Chk2 protein
Molecular Weight: ∽70 kDa
Positive Control: HeLa cells
Cellular Localization: Nuclear
Recommended for:
- Western Blotting
- Immunofluorescence
- Immunoprecipitation (Native verified)
Note:
USA: RUO; Int'l: RUO
Specifications
| Chk2 Ab-1 | |
| Immunofluorescence, Immunoprecipitation, Western Blot | |
| Unconjugated | |
| Mouse | |
| Cell Cycle | |
| Recombinant Chk2 protein | |
| Primary |
| 2CHK01; same as DCS-293 | |
| Monoclonal | |
| Concentrated | |
| RUO | |
| Human | |
| IgG2a κ |
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