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Chk2, Polyclonal, Bethyl Laboratories Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Bethyl Laboratories, IncSupplier Diversity Partner A300620AM

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Catalog No. 50-155-8063


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
Specifications

Specifications

Chk2
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
O96017
RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53
Rabbit
IgG
100 μl
4° C
Primary
11200
Western Blot
Unconjugated
CHEK2
liquid
CHEK2
Between 500 and C-term
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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