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CHMP4B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550380

Catalog No. PA550380


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Description

Description

The antibody detects endogenous levels of total CHMP4B protein.

CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
Specifications

Specifications

CHMP4B
Polyclonal
Unconjugated
CHMP4B
Liquid
CHMP4B
Fusion protein corresponding to a region derived from internal residues of human charged multivesicular body protein 4B
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
1.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9H444, Q9D8B3
C20orf178, SHAX1
Rabbit
IgG
100 μL
-20°C
Primary
128866, 75608
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