Cholera Toxin beta Monoclonal Antibody (3D11), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA121550

Catalog No. PIMA121550

Description

MA1-21550 detects Beta subunit-Cholera Toxin in Bacteria samples. MA1-21550 has been successfully used in ELISA and IHC procedures. MA1-21550 immunogen corresponds to Purified beta subunit of cholera toxin. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Cholera toxin (sometimes abbreviated to CTX, Ctx, or CT) is a protein complex secreted by the bacterium Vibrio cholerae. CTX is the causative agent of cholera infection. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP. The beta subunit of cholera toxin binds to a GM1-ganglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit.

Specifications

• Antigen: Cholera Toxin beta
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Bacteria
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry
• Concentration: 3.3 mg/mL
• Gene Alias: beta subunit cholera toxin; CTB; VC1456; CTX
• Immunogen: Purified beta subunit of cholera toxin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid