DescriptionChromogranin A Monoclonal specifically detects Chromogranin A in Human, Mouse, Rat, Porcine, Monkey, Guinea Pig (Negative), Rabbit (Negative), Sheep (Negative) samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.
|Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml|
|Human, Mouse, Rat, Porcine, Primate, Guinea Pig (Negative), Rabbit (Negative), Sheep (Negative)|
|Store at 4C.|
|Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)|
|Apoptosis, Cancer, Neuronal Cell Markers|
|PBS with 0.05% BSA. with 0.05% Sodium Azide|
|betagranin (N-terminal fragment of chromogranin A), CGA, chromogranin A (parathyroid secretory protein 1), chromogranin-A, parathyroid secretory protein 1, Pituitary secretory protein I, SP-I|
|Protein A purified|
|Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.|
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