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Tocris Bioscience™ CID 16020046

Selective GPR55 antagonist

Manufacturer:  Tocris Bioscience™ 4959/10

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Catalog No. 49-591-0R

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.

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Description

Description

Selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21µM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase,µ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.
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