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CID 16020046, Tocris Bioscience™

Selective GPR55 antagonist

Manufacturer:  Tocris Bioscience 4959/5

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Catalog No. 49-595


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Description

Description

Selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.
Specifications

Specifications

4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid
>99%
Observed MW: 425.44
834903-43-4
C25H19N3O4
5mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

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