Tocris CID 16020046
Selective GPR55 antagonist
Manufacturer: Tocris 4959/10
DescriptionSelective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21µM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase,µ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.
- Chemical Name: 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid
- Formula: C25H19N3O4
- CAS Number: 834903-43-4
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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