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CISD2 Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549425

Catalog No. PA549425

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
Specifications

Specifications

CISD2
Polyclonal
PBS with 0.09% sodium azide
Q9CQB5
CDGSH iron-sulfur domain-containing protein 2, cisd2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
67006
Western Blot
Unconjugated
Cisd2
Liquid
CISD2
KLH conjugated synthetic peptide between 110-144 amino acids from the human region of DANRE cisd2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Documents
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