CISD2 Mouse anti-Human, Clone: OTI4D12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527296
DescriptionDefects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CISD2, CDGSH iron-sulfur domain-containing protein 2, endoplasmic reticulum intermembrane small protein, ERIS, mitoNEET related 1, miner1, nutrient-deprivation autophagy factor-1, NAF-1, zinc finger CDGSH-type domain 2, ZCD2, WFS2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of CISD2 produced in E.coli|
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